Diclazepam is a positive allosteric modulator of the benzodiazepine receptors, paticulary the ‘diazepam sensitive’ sites. It was designed and developed by a team at Hoffmann-La Roche, led by Leo Sternbach (US Patent 3136815). While Etizolam is a thienodiazepine research chemical compound that is a benzodiazepine analog. The etizolam molecule is different from a benzodiazepine in that the benzene ring has been substiuted by a thiophene ring. It contains amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. ..
There is quite a lot of controversy across Europe over legal highs at the moment which I wish only to deal with the facts to allow you to make your own decision and opinion on them. I want to give you as much information about legal highs as I can which I have sourced from reputable drug information services and websites such as Talk To Frank. I hope the information I provide gives you the knowledge on whether or not you want to take them, as from my experience if you’re going to take something you are going to take it regardless of what anyone says to you and only you can make the decision. W..
Contrary to popular belief, Legal Highs Store was the first online based head-shop & alternative lifestyle community to start accepting Bitcoin payments, so if anyone ever tells you otherwise just call them a dirty liar and point them in our direction. We temporarily stopped taking Bitcoin a while back, but as of today our payment facilities are up and running once more, meaning you can purchase absolutely anything from our legal highs & accessories range in exchange for your Bitcoin. For the uninitiated amongst you, Bitcoin is an innovative form of decentralised virtual currency. These pay..
Although marijuana (cannabis) has been used in medicine for thousands of years, its place as a drug in modern medicine has been the subject of intense debate. Among the earliest Western medical reports was one written in 1839 by William O’Shaughnessy, an Irish physician working in India. He noted that cannabis was nontoxic in animals and that it suppressed convulsions and relieved muscle spasms and pain in his patients. In 1912, the author of a leading textbook of therapeutics spoke with praise about cannabis’s value in relieving cough, pain, menstrual cramps, and the tremors of Parkinson’s di..
The minister in charge of drug strategy Norman Baker (as a typical party loving Liberal Democrat) has called on the government to relax laws on cannabis in the UK. He has cited the mounting evidence of marijuana’s medicinal properties as his motive, and the positive effects these properties could have on individuals in need. Mr. Baker has noted that ‘credible people’ in British society are having to break the law by seeking to alleviate the their illnesses, and that recourses are being wasted on prosecuting these people. The minister has today written to the health secretary Jeremy Hunt to ..
In 1860, Albert Niemann, a chemistry graduate student at Göttingen University, published his doctoral dissertation, which described the isolation of cocaine from coca leaves and the numbness it caused when applied to his tongue. By 1880, reports of cocaine’s miraculous properties abounded. It was purported to cure morphine and alcohol addiction, tuberculosis, and even impotency. The young Viennese physician Sigmund Freud used cocaine in an attempt to cure a friend of morphine addiction; he succeeded in transferring the friend’s addiction to cocaine. In 1884, Freud’s colleague, the Austria..
In my previous blog posts I’ve talked about various potential applications of Salvia, such as an antidepressant or a treatment for addiction. Another large area of research into this unique plant is focussed on investigating the analgesic (painkilling) properties of Salvinorin A, the main psychedelic constituent of Salvia. A common issue with modern painkillers is the fact that they are often very addictive. Many effective painkillers, such as morphine or codeine, are mu-opioid receptor (MOR) activators. Addiction can result from improper use of opioids like morphine. An ideal painkiller wo..
On Friday, April 16, 1943, Swiss chemist Albert Hofmann felt ill and left his Sandoz laboratory mid-afternoon. Lying down at home, he reported that “there surged in upon me an uninterrupted stream of fantastic images of extraordinary vividness and accompanied by intense, kaleidoscope-like play of colors.” Suspecting a link between these effects and a chemical on which he had been working—initially synthesized in 1938 and then put aside—the following Monday he ingested an extremely small amount of the chemical: 250 micrograms (0.25 mg). Forty minutes later, during his “bicycle day” ride home an..
A new reseach paper, published on 19th August, compared 21,967 users of "psychedlic drugs" with a representative sample of the population (130,152 total) to determine the effects of LSD, psilocybin and peyote on mental health. Have a guess at what they found... “There were no significant associations between lifetime use of any psychedelics, lifetime use of specific psychedelics (LSD, psilocybin, mescaline, peyote), or past year use of LSD and increased rate of any of the mental health outcomes. Rather, in several cases psychedelic use was associated with lower rate of mental healt..
As an antianxiety drug, Librium was a great success. Three year later, in 1963, Valium appeared on the market. Not only the leading hitter in the benzodiazepine lineup, this drug also became one of the best selling of all pharmaceuticals ever! Valium (diazepam) extended its therapeutic uses beyond anxiety to insomnia, muscle spasms, acute alcohol withdrawal, and preoperative sedation, and, via injection, to control status epilepticus, a life-threatening condition in which seizures persist without letup for more than thirty minutes. For many of these conditions, it represented the first or seco..
At some point in 2009, I decided we needed a photo of some legal highs to spruce up the website a bit, so I grabbed a pack of everything we stocked at the time and half-heartedly arranged them by hue, grabbed our 5 megapixel point-and-shoot camera (typical of the 00's - took about 6 rechargeable AA batteries, used some weird ancestor of an SD card, piss-poor image quality, grain-central) and grabbed a quick snap. That'll do, I must have thought. Original "legal highs" photo from 2009 And it DID do! Pretty good going actually. I wheel it out every time I've written some content about ..
Timothy Leary was a psychology professor at Harvard University during the 1950s and 1960s. At that time, many scientists were studying LSD. Leary began to experiment with the drug, too. He gave it to prison inmates and to some of his students, and he often took it himself. Leary believed that LSD’s mind-altering effects could help people achieve spiritual and intellectual awakenings, and he encouraged people to use it. He coined the phrase “Turn on, tune in, and drop out,” which became popular among the 1960s counterculture. Leary helped spark the Psychedelic Movement, which was based on using..
Public awareness of Salvia divinorum is always growing; mostly thanks to scaremongering media reports about the new ‘legal high’ that is threatening our safety. Unfortunately, the majority of instances of Salvia use we hear about in the media focus on reckless or irresponsible use of the plant. What we don’t hear a lot about is the responsible use of Salvia, or the amazing medical potential of the plant. Hundreds of scientists are currently studying Salvia in the hope of finding a cure for addiction, or developing groundbreaking new painkillers. It’s important that the people in government who..
Other Names: Ambihuasca, ambiwáska, ayawáska, biaxii, caji, caapi, calawaya, cipó, daime, daba, dapá, djungle tea, djunglehuasca, doctor, dschungel ambro- sia, el remdio, hoasca, honi, kaapi, kahi, hakpi, la purga, meti, mihi, natema, natemä, nepe, nepi, nixi honi, nixi paé, notema, ohoasca, pilde, pildé, pinde, pindé, remedio, sachahuasca, snato daime, tea, the brew, vegetal, yagé, yajé, yaxé Identification: A shrub or climbing, twisting vine (or liana) with chocolate brown, smooth bark. Leaves are opposite, 6"–7" long, 3" wide, oval, double tapered, margins entire. Flowers are pink with 1..